Expression of a GPR54-like but no agonistic effect of mammalian kisspeptins in trout

Goupil A.S., Lareyre J.J., Le Bail P.Y., Kah O., Caraty A., Le Gac F.

Date de parution: juillet 2008
Volume: 32
Number: 2 suppl.
Pagination: 041-042
Editeur: Société Française d'Ichtyologie

Kisspeptins and their G protein-coupled receptor, play a fundamental role in the control of reproductive function in mammals. Here we show that the anterior brain and testis of the trout express a GPR54-like transcript. Trout at 3 stages of maturation were submitted to in vivo treatment with large amounts or repeated injections of mouse or human C terminal decapeptides (KISS10). Mammalian KISS10 did not increase LH or testosterone hormone concentrations in the trout blood and were not able to stimulate ovulation or spermiation. Results even evoked a potential antagonistic effect of these peptides.

Mots-clés: GPR54 - Kiss - LH - Ovulation - Testosterone - Trout
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