Estrogen regulation of multiple vitellogenin and estrogen receptor genes and of the growth hormone-insulin like growth factor axis in tilapia

Davis L., Hiramatsu N., Sullivan C.V., Hirano T., Grau E.G.

Published date: July 2008
Volume: 32
Number: 2 suppl.
Pagination: 242-243
Publisher: Société Française d'Ichtyologie

We studied the regulation of multiple vitellogenin (Vg) and estrogen receptor (ER) genes, and the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis by estradiol (E2) in liver and gonads of male, female, and E2-treated male tilapia. Plasma Vg and liver expression of three Vg genes and ERα increased in females and E2-treated males, while plasma IGF-I and liver expression of ERß, IGF-I and GH receptor (GHR) were reduced. Expression of Vgs, ERs, IGF-I and GHR was higher in ovary than in testis. These results suggest that E2 acts on the liver to shift energy away from somatic growth towards Vg production.

Keywords: Estrogen receptor - Growth hormone - Vitellogenin
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